Florfenicol is a fluorinated synthetic analog of thiamphenicol, mainly used as a antibiotic in veterinary medicine.
CAS No. :
73231-34-2EINECS :
642-986-0Package :
25KG/DRUMBrand :
TOPINCHEM®Origin :
CHINAFormula :
C12H14Cl2FNO4SMinimum Order :
100KGItem :
FlorfenicolDescription
Florfenicol is a thiamphenicol derivative with the same mechanism of action as chloramphenicol (inhibition of protein synthesis). However, it is more active than either chloramphenicol or thiamphenicol, and may be more bactericidal than previously thought against some pathogens. Florfenicol has a broad spectrum of antibacterial activity that includes all organisms sensitive to chloramphenicol, gram-negative bacilli, gram-positive cocci, and other atypical bacteria such as mycoplasma.
Specification
Testing Items | Specifications | Results | |||||||
Character | White or almost-white powder or crystalline powder,odorless |
Almost-white crystalline powder,odorless |
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Solubility | Very soluble in dimethylformamide,soluble in methanol,Sparingly soluble in acetic acid,Very slightly soluble in trichloromethane,Practically insoluble in water |
Complies | |||||||
m.p | 152℃~156℃ | 154~155℃ | |||||||
Specificoptical rotation |
-16°~-19° | -18° | |||||||
Identification | (1)The retention time of the main peak obtained for the test sample should correspond to the standard |
Complies | |||||||
(2)The IR spectrum of sample is identical with the reference standard |
Complies | ||||||||
pH | 4.5~6.5 | 6.2 | |||||||
Chlorine | ≤0.02% | <0.02% | |||||||
Fluorine | ≥4.8% | 4.9% | |||||||
Water | ≤0.5% | 0.04% | |||||||
Residue on ignition | ≤0.1% | <0.1% | |||||||
Heavy metals | ≤20ppm | <20ppm | |||||||
Max impurity | ≤0.5% | 0.24% | |||||||
Total impurities | ≤2.0% | 0.59% | |||||||
Assay | ≥98.0%(Anhydrous substance) | 99.4% | |||||||
Methanol | ≤3000ppm(In-house) | <1.2ppm | |||||||
Ethanol | ≤5000ppm(In-house) | 240ppm | |||||||
Dichloromethane | ≤600ppm(In-house) | <3.2ppm |