CAS No. :
1405-20-5EINECS :
215-774-7Package :
2KG/TINBrand :
TOPINCHEM®Origin :
CHINAFormula :
C56H100N16O17SMinimum Order :
2KGItem :
Polymyxin B Sulfate
Description
Polymyxin B (polymyxin b sulfate) is an antibiotic used to treat bacterial infections such as urinary tract infections, meningitis, blood infections, and eye infections. Polymyxin B is available in generic form.
Specification
| Tests | Specifications | Results |
| Description | White or almost white powder,hygroscopic | Conforms |
| Identification | HPLC identification test,Conforms |
Conforms
|
| Areddish violet color is produced,Conforms | ||
| Meets the requirements of the test for Sulfate ,Conforms | ||
| PH(0.5%) | 5.0～7.5 | 5.9 |
| Loss on drying | ≤7.0% | 4.20% |
|
Res
idue on ignition |
≤5.0% | 0.25% |
| Any impurity:≤3.0% | 2.10% | |
| Related substances,HPLC | Sum of impurity:≤17.0% | 7.20% |
| Total viable aerobic count | ≤100CFU/g | Conform |
| Potency(Dried basis) | ≥6000IU/mg | 8135IU/mg |
| Assay HPLC (Dried basis) | Sum of polymyxin B1,B2,B3 and B1-I:≥80.0% | 96.10% |
| Polymyxin B3:≤6.0% | 1.30% | |
| Polymyxin B1-I:≤15.0% | 14.30% | |
| Particle size (Neither USP nor EP has this) |
99.0%:Not more than 30μm by vol. | Conforms |
| 90.0%:Not more than 20μm by vol | ||
| 75.0%:Not more than 15μm by vol | ||
| 35.0%:Not more than 5μm by vol | ||
| Mean diameter:Not more than 10μm |
Application
Antibiotic Polymyxin B Sulfate used for the treatment of serious gram-negative infections, including those caused by Pseudomonas. However, aminoglycosides and extended spectrum penicillins are generally the drugs of choice for these conditions.
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